Daily case
The same case for everyone. Refreshed at midnight.
400 cases · 20+ specialties
Coming soon to iOS
A new patient every day.A new patient every day.
Train diagnostic reasoning in 5 minutes.
How many clues do you need to crack today's case?
- Distant
- Chapter
- Group
- Subcategory
- Exact
NEXO is a daily medical diagnosis game for doctors and medical students. Each day, a new fictional clinical case is published with up to 6 progressive clues. Players search for ICD-10 codes and receive proximity feedback across 5 levels: exact, subcategory, group, chapter, or distant. Beyond the daily case, NEXO offers a Continents mode (104 cases organized by regional epidemiology across Africa, Americas, Asia, Europe, and Oceania) and a Multimedia mode (124 cases with clinical imaging and auscultation, including X-ray, CT, MRI, ultrasound, ECG, upper endoscopy, colonoscopy, dermatoscopy, fundoscopy, physical exam, histopathology, blood smear, karyotype, PET/CT, otoscopy, mammography, colposcopy, and cardiac and respiratory audio). In total, 624 clinical cases across 20 medical specialties, available in 6 languages (Portuguese, English, Spanish, French, German, and Russian). The goal is to train diagnostic reasoning in 5 minutes a day, with a global leaderboard, achievements, and daily streaks.
How it works
How does NEXO work?
01
Read the clues
Six progressive clues. The first is visible; reveal the rest only if you need them. Fewer clues, more points.
Case #247
1
67-year-old male patient.
2
Crushing chest pain for the past 2 hours, radiating to the left arm.
3
Associated cold sweat and dyspnea.
Your attempt
CID-10DiagnosisProximity
I21.0Acute myocardial infarctionExact
I25.1Coronary artery diseaseGroup
J18.9Unspecified pneumoniaDistant
02
Submit your diagnosis
Each attempt shows how close you are to the correct diagnosis. ICD-10 helps guide your choices.
03
Climb the ranks
Collect your wins, stack synapses, climb the leaderboard, and challenge your peers.
NEXO #247 | Cardiology
3/6 clues
nexo.wiki.br
Game modes
Three modes. One way of thinking.
One new case every day for every player. Cases by regional epidemiology. Cases with clinical imaging and auscultation.
Synapses
Continents
Travel around the globe exploring endemic and prevalent pathologies of each region.
104 cases · 5 regions
Synapses
Multimedia
Sharpen your clinical senses as if on call: read images, sounds, and real findings.
X-RayCTMRIUSECGEndoscopyColonoscopyDermatoscopyFundoscopyPhysical examHistopathologyBlood smearKaryotypePET/CTOtoscopyMammographyColposcopyAuscultation
124 cases, 18 modalities
Chest X-ray
Pulmonary tuberculosis
Histopathology
Colorectal adenocarcinoma
Physical exam
Petechiae
Cardiac auscultation
Aortic regurgitation
What sets it apart
The mistake teaches.When it has an address.
In a quiz, you miss and that's it. Here, missing I21 and getting same chapter tells you that you were in diseases of the circulatory system. Not somewhere random.
You searched
I21.0Acute myocardial infarction
ExactAcute myocardial infarction
I21.0SubcategoryMyocardial infarction, unspecified
I21.9GroupAngina pectoris
I20ChapterHeart failure
I50DistantPneumonia
J18Five tiers. Every mistake has an address.
NEXO Core
The brain behind every case.A stitched clinical library.
AI generators can produce clinical cases in seconds. Few can guarantee that the case has any grounding. NEXO Core is the layer that changes that equation. Every disease, syndrome, exam, clinical finding, and ICD-10 code lives as its own page, linked to the pages clinical reasoning recognizes as neighbors. Pneumonia talks to its etiologic agent, to its radiologic pattern, and to its differential diagnoses. When a case is generated, it crosses that mesh before being approved. No clue holds without appearing among the neighboring concepts of the proposed diagnosis. It is structural audit, not reading review.
The graph groups six anchor diseases and their neighboring concepts:
- Acute myocardial infarction, ICD code I21.0 within group I20-I25, connected to unstable angina, acute pericarditis, pulmonary thromboembolism, elevated troponin, ST-segment elevation, and the cardiology chapter.
- Pneumonia, ICD code J18.1 within group J12-J18, connected to Streptococcus pneumoniae, tuberculosis, radiologic consolidation, productive cough, and the infectious diseases chapter.
- Ischemic stroke, ICD code I63.9 within group I60-I69, connected to hemorrhagic stroke, non-contrast CT, sudden hemiparesis, and the neurology chapter.
- Sepsis, ICD code A41.9 within group A30-A49, connected to septic shock, elevated lactate, refractory hypotension, and the infectious diseases chapter.
- Preeclampsia, ICD code O14.9 within group O10-O16, connected to eclampsia, HELLP syndrome, 24-hour proteinuria, gestational hypertension, and the obstetrics chapter.
- Melanoma, ICD code C43.9 within group C43, connected to basal cell carcinoma, dysplastic nevus, ABCDE dermoscopy, asymmetric lesion, and the oncology chapter.
11,283clinical concepts
acute myocardial infarction, ischemic stroke, sepsis, community-acquired pneumonia, preeclampsia, melanoma, type 2 diabetes, infective endocarditis
3,124chapters across 23 textbooks
Harrison, Sabiston, DeVita, Mandell, Williams Obstetrics, Nelson, Braunwald, Brenner, Merritt, Kanski, among other works
26,361connections between concepts
cirrhosis linked to esophageal varices, ascites, and hepatic encephalopathy; pulmonary tuberculosis linked to pleural effusion and apical cavitation; systemic lupus erythematosus (SLE) linked to lupus nephritis and antinuclear antibodies (ANA)
Frequently asked questions
Before you start.
What is NEXO?
A daily game of diagnostic reasoning. You read 6 progressive clues and submit the diagnosis you think lies behind the case. ICD-10 enters as the ruler. The feedback measures the distance from your guess to the answer in the ICD tree: exact code, same subcategory, same group, same chapter, or distant.
How does NEXO treat error?
As information, not as failure. Guessing cholecystitis instead of appendicitis falls in the same acute chapter: you thought right, you missed close. Guessing heart attack falls in another chapter: you thought far. Both errors get different feedback because they mean different things at the bedside.
Is NEXO a USMLE, MCCQE, PLAB simulator?
No. It is also not a flashcard app, an AI tutor, or a clinical reference. Those categories treat medical knowledge as content to be studied. NEXO treats diagnostic reasoning as practice to be done.
Who is it for?
For those who enjoy the challenge of diagnosis. Students, professionals, specialists. One case fits in the five minutes between two consultations, the ten minutes on the train before a shift, the pause where you were about to scroll the feed.
Do I need to pay?
No. The daily case is free, forever. Not as an acquisition tier. As a stance: the daily pulse of clinical reasoning does not live behind a paywall. Continents mode, organized by regional epidemiology, and Multimedia mode, with real clinical imaging and auscultation, are unlockable with sinapses earned in the daily case, on any plan. Pro and Max open volume beyond the daily case and multiply sinapses and XP by 2x and 4x. Paying does not buy correctness. It buys repetition.
Team
Behind NEXO.
Thiago Longo Moraes
Co-founder · CEO
Medical student. Founder and CEO of Medfinder. Author of the trilogy Artificial Intelligence in Healthcare.
Alexei Peter dos Santos
Co-founder · Doctor
Clinical oncologist trained at UFPel. Master in Educational Technology from the University of British Columbia. Former Vice-President of the Brazilian Society of Clinical Oncology.
Rafael Guimarães Malanga
Co-founder · Developer
Data scientist. MSc in Deep Learning for radiographic imaging.